Gene Dubowchik: search on Z-Library

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1

Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates: Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity

Dubowchik, Gene M., Firestone, Raymond A., Padilla, Linda, Willner, David, Hofstead, Sandra J., Mosure, Kathleen, Knipe, Jay O., Lasch, Shirley J., Trail, Pamela A.

Journal:

Bioconjugate Chemistry

Year:

2002

Language:

english

File:

PDF, 190 KB

english, 2002

2

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

Gene M. Dubowchik, Raymond A. Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 367 KB

english, 1998

3

Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine

Lipton, Richard B., Croop, Robert, Stock, Elyse G., Stock, David A., Morris, Beth A., Frost, Marianne, Dubowchik, Gene M., Conway, Charles M., Coric, Vladimir, Goadsby, Peter J.

Journal:

New England Journal of Medicine

Year:

2019

File:

PDF, 263 KB

2019

4

Stereoselective Synthesis of New Conformationally Restricted Analogues of a Potent CGRP Receptor Antagonist

Zuev, Dmitry, Michne, Jodi A., Huang, Hong, Beno, Brett R., Wu, Dedong, Gao, Qi, Torrente, John R., Xu, Cen, Conway, Charles M., Macor, John E., Dubowchik, Gene M.

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 132 KB

english, 2005

5

Synthesis of an immunoconjugate of camptothecin

Michael A Walker, Gene M Dubowchik, Sandra J Hofstead, Pamela A Trail, Raymond A Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 112 KB

english, 2002

6

An Efficient Sequence for the Preparation of Small Secondary Amine Hydrochloride Salts for Focused Library Generation Without Need for Distillation or Chromatographic Purification.

Gene M. Dubowchik, Jodi A. Michne, Dmitry Zuev

Journal:

Year:

2004

File:

PDF, 26 KB

2004

7

Synthesis, Structure—Activity Relationships, and Anxiolytic Activity of 7-Aryl-6,7-dihydroimidazoimidazole Corticotropin-Releasing Factor 1 Receptor Antagonists.

Xiaojun Han, Gene M. Dubowchik, et al. et al.

Journal:

Year:

2005

File:

PDF, 18 KB

2005

8

2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy

Gene M. Dubowchik, Jodi A. Michne, Dmitry Zuev, Wendy Schwartz, Paul M. Scola, Clint A. James, Edward H. Ruediger, Sokhom S. Pin, Kevin D. Burris, Lynn A. Balanda, Qi Gao, Dedong Wu, Lawrence Fung, Tr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003

9

Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages

Gene M Dubowchik, Shilpa Radia, Harold Mastalerz, Michael A Walker, Raymond A Firestone, H Dalton King, Sandra J Hofstead, David Willner, Shirley J Lasch, Pamela A Trail

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 133 KB

english, 2002

10

Asymmetric Synthesis of Heterocyclic Analogues of a CGRP Receptor Antagonist for Treating Migraine

Luo, Guanglin, Chen, Ling, Conway, Charles M., Kostich, Walter, Macor, John E., Dubowchik, Gene M.

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 473 KB

english, 2015

11

Controlled conformational changes in covalently-linked dimeric porphyrins

Dubowchik, Gene M., Hamilton, Andrew D.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1985

Language:

english

File:

PDF, 213 KB

english, 1985

12

Synthesis and SAR of Calcitonin Gene-Related Peptide (CGRP) Antagonists Containing Substituted Aryl-Piperazines and Piperidines

Civiello, Rita L., Han, Xiaojun, Beno, Brett R., Chaturvedula, Prasad V., Herbst, John J., Xu, Cen, Conway, Charles M., Macor, John E., Dubowchik, Gene M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 403 KB

english, 2016

13

Enantioselective synthesis of aminobenzazepinones

C.V.C. Prasad, Stephen E. Mercer, Gene M. Dubowchik, John E. Macor

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 159 KB

english, 2007

14

Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists

Tora, George, Degnan, Andrew P., Conway, Charles M., Kostich, Walter A., Davis, Carl D., Pin, Sokhom S., Schartman, Richard, Xu, Cen, Widmann, Kimberly A., Macor, John E., Dubowchik, Gene M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.95 MB

english, 2013

15

Catalytic Asymmetric Syntheses of α-Amino and α-Hydroxyl Acid Derivatives

Han, Xiaojun, Jiang, Xiang-Jun, Civiello, Rita L., Degnan, Andrew P., Chaturvedula, Prasad V., Macor, John E., Dubowchik, Gene M.

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 154 KB

english, 2009

16

An efficient synthesis of N-arylated, orthogonally protected racemic aspartates

Guanglin Luo, Ling Chen, Rita Civiello, Gene M. Dubowchik

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 125 KB

english, 2008

17

Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay

Gene M Dubowchik, Jonathan L Ditta, John J Herbst, Sagarika Bollini, Alexander Vinitsky

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 173 KB

english, 2000

18

Cathepsin B-sensitive dipeptide prodrugs. 2. Models of anticancer drugs paclitaxel (Taxol®), mitomycin C and doxorubicin

Gene M. Dubowchik, Kathleen Mosure, Jay O. Knipe, Raymond A. Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 367 KB

english, 1998

19

Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide

Kristen Ditaranto-Desimone, Mitsuo Saito, T.L Tekirian, Mariko Saito, Martin Berg, Gene Dubowchik, Brian Soreghan, Stefani Thomas, Neville Marks, Austin J Yang

Journal:

Brain Research Bulletin

Year:

2003

Language:

english

File:

PDF, 286 KB

english, 2003

20

Antibody Drug Conjugates for Treatment of Breast Cancer: Novel Targets and Diverse Approaches in ADC Design

Trail, Pamela A., Dubowchik, Gene M., Lowinger, Timothy

Journal:

Pharmacology & Therapeutics

Year:

2017

Language:

english

File:

PDF, 1.48 MB

english, 2017

21

Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists

George N. Karageorge, Stephen Bertenshaw, Lawrence Iben, Cen Xu, Nathan Sarbin, Anthony Gentile, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 255 KB

english, 2004

22

Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability

Andrew P. Degnan, Charles M. Conway, Richard A. Dalterio, Robert Macci, Stephen E. Mercer, Richard Schartman, Cen Xu, Gene M. Dubowchik, John E. Macor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.09 MB

english, 2009

23

Synthesis of tetrameric and hexameric cyclo-porphyrins

Dubowchik, Gene M., Hamilton, Andrew D.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1987

Language:

english

File:

PDF, 292 KB

english, 1987

24

Serendipitous oxidation product of BIBN4096BS: A potent CGRP receptor antagonist

Dasgupta, Bireshwar, Kozlowski, Edward, Schroeder, Daniel R., Torrente, John R., Xu, Cen, Pin, Sokhom, Conway, Charlie M., Dubowchik, Gene M., Macor, John E., Vrudhula, Vivekananda M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.01 MB

english, 2014

25

Synthesis and structure–activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists

Xiaojun Han, Sokhom S. Pin, Kevin Burris, Lawrence K. Fung, Stella Huang, Matthew T. Taber, Jie Zhang, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 567 KB

english, 2005

26

Induction of cell death by the lysosomotropic detergent MSDH

Wei Li, XiMing Yuan, Gunnar Nordgren, Helge Dalen, Gene M. Dubowchik, Raymond A. Firestone, Ulf T. Brunk

Journal:

Year:

2000

Language:

english

File:

PDF, 675 KB

english, 2000

27

Reversal of doxorubicin resistance and catalytic neutralization of lysosomes by a lipophilic imidazole

Gene M. Dubowchik, Linda Padilla, Kurt Edinger, Raymond A. Firestone

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1994

Language:

english

File:

PDF, 566 KB

english, 1994

28

Towards a synthetic model of the structure of the photosynthetic reaction centre

Dubowchik, Gene M., Hamilton, Andrew D.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1986

Language:

english

File:

PDF, 304 KB

english, 1986

29

Asymmetric Synthesis of the Major Metabolite of a Calcitonin Gene-Related Peptide Receptor Antagonist and Mechanism of Epoxide Hydrogenolysis

Luo, Guanglin, Chen, Ling, Conway, Charles M., Kostich, Walter, Johnson, Benjamin M., Ng, Alicia, Macor, John E., Dubowchik, Gene M.

Journal:

Journal of Organic Chemistry

Year:

2017

Language:

english

File:

PDF, 642 KB

english, 2017

30

Monoclonal antibody mediated intracellular targeting of tallysomycin S10b

Michael A Walker, H.Dalton King, Richard A Dalterio, Pamela Trail, Raymond Firestone, Gene M Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 277 KB

english, 2004

31

The synthesis of branched steroidal prodrugs of nitrogen mustard for antitumor targeting via reconstituted LDL

Gene M. Dubowchik, Raymond A. Firestone

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 281 KB

english, 1994

32

Monoclonal antibody drug immunoconjugates for targeted treatment of cancer

Pamela A. Trail, Dalton H. King, Gene M. Dubowchik

Journal:

Cancer Immunology, Immunotherapy

Year:

2003

Language:

english

File:

PDF, 238 KB

english, 2003

33

Novel polyamide inducers of HL-60 cellular differentiation

Gene M. Dubowchik, Laurie A. Cornell, Alfred R. Crosswell, Raymond A. Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 394 KB

english, 1993

34

Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs

Gene M Dubowchik, Michael A Walker

Journal:

Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 657 KB

english, 1999

35

Syntheses of aza and fluorine-substituted 3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-ones

Xiaojun Han, Rita L. Civiello, Stephen E. Mercer, John E. Macor, Gene M. Dubowchik

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 178 KB

english, 2009

36

Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group

Guanglin Luo, Ling Chen, Rita Civiello, Sokhom S. Pin, Cen Xu, Walter Kostich, Michelle Kelley, Charles M. Conway, John E. Macor, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

37

2-Arylaminothiazoles as High-Affinity Corticotropin-Releasing Factor 1 Receptor (CRF1R) Antagonists: Synthesis, Binding Studies and Behavioral Efficacy.

Gene M. Dubowchik, et al. et al.

Journal:

Year:

2004

File:

PDF, 104 KB

2004

38

An acid-cleavable linker stable at neutral pH that releases doxorubicin at lysosomal pH

Gene M. Dubowchik, Linda M. Padilla, Raymond A. Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 272 KB

english, 1993

39

Calcitonin gene-related peptide (CGRP) receptor antagonists: Novel aspartates and succinates

Guanglin Luo, Ling Chen, Sokhom S. Pin, Cen Xu, Charles M. Conway, John E. Macor, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 3.82 MB

english, 2012

40

Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor

Prasad V. Chaturvedula, Sokhom Pin, George Tholady, Charlie M. Conway, John E. Macor, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 552 KB

english, 2012

41

2-Aryl-2,2-difluoroacetamide FKBP12 Ligands: Synthesis and X-ray Structural Studies

Dubowchik, Gene M., Vrudhula, Vivekananda M., Dasgupta, Bireshwar, Ditta, Jonathan, Chen, Ti, Sheriff, Steven, Sipman, Karin, Witmer, Mark, Tredup, Jeffrey, Vyas, Dolatrai M., Verdoorn, Todd A., Bolli

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 151 KB

english, 2001

42

An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes

Xiaojun Han, Rita Civiello, Sokhom S. Pin, Kevin Burris, Lynn A. Balanda, Jay Knipe, Shelly Ren, Tracey Fiedler, Kaitlin E. Browman, Robert Macci, Matthew T. Taber, Jie Zhang, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 152 KB

english, 2007

43

Enantioselective synthesis of constrained phenylalanine analogues

Prasad V. Chaturvedula, Stephen E. Mercer, Leatte Guernon, John E. Macor, Gene M. Dubowchik

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 1.58 MB

english, 2010

44

An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification

Gene M. Dubowchik, Jodi A. Michne, Dmitry Zuev

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 242 KB

english, 2004

45

Synthesis and Structure—Activity Relationship of Imidazo[1,2-a]benzimidazoles (XII) as Corticotropin-Releasing Factor 1 Receptor Antagonists.

Xiaojun Han, Sokhom S. Pin, Kevin Burris, Lawrence K. Fung, Stella Huang, Matthew T. Taber, Jie Zhang, Gene M. Dubowchik

Journal:

Year:

2005

File:

PDF, 39 KB

2005

46

Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis

Dmitry Zuev, Jodi A. Michne, Sokhom S. Pin, Jie Zhang, Matthew T. Taber, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 258 KB

english, 2005

47

Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-β-Lactamase fusion protein

Vivekananda M. Vrudhula, David E. Kerr, Nathan O. Siemers, Gene M. Dubowchik, Peter D. Senter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 150 KB

english, 2003

48

Amines That Transport Protons across Bilayer Membranes: Synthesis, Lysosomal Neutralization, and Two-Phase pKa Values by NMR

Dubowchik, Gene M., Padilla, Linda, Edinger, Kurt, Firestone, Raymond A.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 352 KB

english, 1996

49

Improved Cytotoxicity of Antitumor Compounds Deliverable by the LDL Pathway

Dubowchik, Gene M., Firestone, Raymond A.

Journal:

Bioconjugate Chemistry

Year:

1995

Language:

english

File:

PDF, 1.62 MB

english, 1995

50

Strong interactions in covalently trimeric porphyrins

Dubowchik, Gene M., Hamilton, Andrew D.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1986

Language:

english

File:

PDF, 224 KB

english, 1986

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